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Can Biomarkers for Inflammation Help Diagnostic Tests for Osteoarthritis in Knee Joints?

Unlike other rheumatological conditions a rheumatologist treats, like rheumatoid arthritis (RA), celiac disease (gluten intolerance), or lupus, osteoarthritis, has traditionally been categorized as a non-inflammatory disorder. As the most common form of arthritis, Osteoarthritis affects millions of people every year, resulting from the degeneration of protective cartilage in the knees. OA can lead to permanent joint pain and damage in LA. Rheumatoid arthritis and other rheumatological conditions that also lead to chronic joint pain and deterioration result from inflammation and autoimmune flare-ups that cause the immune system to mistakenly target healthy organs and tissue. It is crucial to get arthritis treatment as early as possible to help prevent severe joint degeneration and to manage the symptoms.

Inflammation Markers and Osteoarthritis

According to the results of a study published in the November 2015 issue of the Arthritis and Rheumatology journal, researchers have found the presence of inflammatory mediators like PGE2 and IL-1β in knee joints affected with osteoarthritis. Inflammatory mediators are molecular compounds that play a role in the process of inflammation.

In the case of the osteoarthritic knee joints examined in the study, the researchers set out to learn whether the inflammatory mediators contributed to the progression of osteoarthritis. Inflammation in the knee joint can be detected in the plasma and peripheral blood leukocytes (PBLs).

After studying symptomatic OA patients over a 24 month period using radiographic progression tests, the study’s authors concluded that certain biomarkers for inflammation could help to identify patients suffering from or at risk for symptomatic osteoarthritis, which could potentially help to develop better screening methods and drug treatments in the future for those in Beverly Hills and worldwide.

“The inflammatory plasma lipid biomarkers PGE2 and 15-HETE identify patients with symptomatic knee OA, and the PBL inflammatory transcriptome identifies a subset of patients with symptomatic knee OA who are at increased risk of radiographic progression. These findings may reflect low-grade inflammation in OA and may be useful as diagnostic and prognostic biomarkers in the clinical development of disease-modifying OA drugs.”

The Symptoms of Osteoarthritis

Learn more about osteoarthritis at

Contact a Rheumatologist in Los Angeles

If you are experiencing symptoms of osteoarthritis (OA), or need a second opinion on a prior diagnosis, contact board certified rheumatologist Dr. Susan Baker at (310) 274–7770 to schedule a consultation today!

Next, learn about some techniques for managing osteoarthritis

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